Distribution of structural polymorphisms of angiotensin converting enzyme and serotonin receptor (5-HT2A) genes among long-living individuals from northwestern Russia

The I/D polymorphism of the angiotensin converting enzyme (ACE) gene and C102T polymorphism of the serotonin receptor gene (5-HT2A) were studied in a group of long-living individuals from northwestern Russia. No significant differences in allele frequencies of these genes were detected between long-living individuals and young people. At the same time, strongly pronounced differences in the 5-HT2A gene A1 and A2 alleles in populations of the northwestern region of the Russian Federation and the United States (0.397 (A1) and 0.603 (A2), and 0.615 (A1) and 0.385 (A2), respectively) were detected. These significant population differences deserve serious attention and a detailed analysis of polymorphism in other serotonin system genes in different populations of Russian Federation.