The promise of single-cell sequencing

被引：0
|
作者：
James Eberwine
Jai-Yoon Sul
Tamas Bartfai
Junhyong Kim
机构：
[1] Perelman School of Medicine,Department of Pharmacology
[2] University of Pennsylvania,The Department of Chemical Physiology
[3] Penn Genome Frontiers Institute,Department of Biology
[4] University of Pennsylvania,undefined
[5] The Scripps Research Institute,undefined
[6] University of Pennsylvania,undefined
来源：
Nature Methods | 2014年 / 11卷
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摘要：
Individual cells of the same phenotype are commonly viewed as identical functional units of a tissue or organ. However, the deep sequencing of DNA and RNA from single cells suggests a more complex ecology of heterogeneous cell states that together produce emergent system-level function. Continuing development of high-content, real-time, multimodal single-cell measurement technologies will lead to the ultimate goal of understanding the function of an individual cell in the context of its microenvironment.
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页码：25 / 27
页数：2
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