Synthesis of 2-aryl-4-(4-β-D-allopyranosyloxyphenyl)4,6,7,8-tetrahydroquinolin-5(1H)-one derivatives under solvent-free conditions and study of sedative activity

被引：0
|
作者：
Congling Yang
Shiming Lv
Ying Li
Shufan Yin
机构：
[1] Sichuan Normal University,College of Chemical and Material Science
[2] Sichuan University,College of Chemistry
来源：
Chemistry of Natural Compounds | 2011年 / 46卷
关键词：
chalcone; 4,6,7,8-tetrahydroquinolin-5(1; )-one; solvent-free; sedative-hypnotic activity;
D O I：
暂无
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学科分类号：
摘要：
Under solvent-free conditions, syntheses of 2-aryl-4-(4-β-D-allopyranosyloxyphenyl)-4,6,7,8tetrahydroquinolin-5(1H)-one derivatives were carried out from chalcone (2a–2e), cyclohexane-1,3-dione (3), and NH4OAc in excellent yield without using any catalysts. The structure of the new compounds were characterized by 1H NMR, IR, and HR-MS spectroscopy. The preliminary bioassay tests of 4a–4j indicated that compounds 4b, 4e, and 4f exhibited potent sedative and hypnotic activity.
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页码：910 / 914
页数：4
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