Leukemia in Patients with Klinefelter Syndrome: A Report of Two Cases

被引:0
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作者
M. Bchir
W. Ayed
H. Ben Neji
O. Kilani
S. Kefi
M. Zarrouk
H. Guermani
S. Hentati
A. Amouri
B. Meddeb
机构
[1] Aziza Othmana University Hospital,Department of Hematology
[2] El Manar Tunis University,Laboratory of Histology and Cytogenetics, Department of Histology and Cytogenetics, Faculty of Medicine of Tunis, Institut Pasteur de Tunis
关键词
Klinefelter syndrome; Acute promyelocytic leukemia; Chronic myelogenous leukemia; Karyotype;
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摘要
Klinefelter syndrome (KS) is a chromosome abnormality characterized by a 47, XXY karyotype associated with hypogonadism and infertility. We present two cases of leukemia in patients with KS. The first patient presented with acute promyelocytic leukemia. He relapsed after the end of treatment. The second patient was diagnosed with chronic myeloid leukemia. Treatment with imatinib failed and the patient presented with myeloid blast crisis.
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页码:66 / 68
页数:2
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