The B cell transmembrane glycoprotein modulates immune signaling. Mice containing specific Cd22 mutations show that the extracellular glycan-binding function is regulatory and indicate unexpected complexity in CD22-ligand interactions.
机构:
Univ Massachusetts, Chan Med Sch, Dept Med, Div Hematol & Oncol, Worcester, MA USAUniv Massachusetts, Chan Med Sch, Dept Med, Div Hematol & Oncol, Worcester, MA USA
Pitarresi, Jason R.
Fitzgerald, Katherine A.
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机构:
Univ Massachusetts, Dept Med, Div Innate Immun, Chan Med Sch, Worcester, MA 01655 USAUniv Massachusetts, Chan Med Sch, Dept Med, Div Hematol & Oncol, Worcester, MA USA