Sorbus aucuparia L. Fruit Is a Source of the Drug for Increasing the Efficiency of Tumor Chemotherapy

被引：0
|
作者：
N. V. Isaikina
G. I. Kalinkina
T. G. Razina
E. P. Zueva
O. Yu. Rybalkina
A. V. Ulirich
E. P. Fedorova
A. B. Shilova
机构：
[1] Siberian State Medical University,Tomsk National Research Medical Center, Russian Academy of Sciences
[2] E.D. Goldberg Scientific Research Institute of Pharmacology and Regenerative Medicine,undefined
[3] National Research Tomsk State University,undefined
来源：
Russian Journal of Bioorganic Chemistry | 2018年 / 44卷
关键词：
rowanberry fruit extracts; phenolic compounds; Lewis lung carcinoma; anthocyanins; antimetastatic activity;
D O I：
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中图分类号：
学科分类号：
摘要：
The composition of phenolic compounds of rowanberry (Sorbus aucuparia L.) fruit extracts prepared with 40% ethanol and 95% acidified ethanol was studied. The differences in the content of flavonoids, including anthocyanins, and phenolic acids were shown. It was found that the antimetastatic activity of cyclophosphamide was most efficiently increased by the rowanberry fruit extract in 95% acidified ethanol enriched in anthocyanins. The aim of the present research was to investigate the effect of hydroalcoholic extracts of rowanberry fruit on the development of Lewis lung carcinoma and the antitumor activity of cyclophosphamide and to reveal the most effective extract containing a phenolic complex for its further study as a promising drug.
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页码：899 / 905
页数：6
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