Gastric emptying in an animal model of human diabetes type 1: relation to endocrine cells

被引：0
|
作者：
M. El-Salhy
机构：
[1] Section for Gastroenterology and Hepatology,
[2] Department of Medicine,undefined
[3] Institution of Public Health and Clinical Medicine,undefined
[4] University Hospital,undefined
[5] S-901 85 Umeå,undefined
[6] Sweden,undefined
来源：
Acta Diabetologica | 2001年 / 38卷
关键词：
Key words Diabetes; Diarrhoea; Endocrine cells; Gastric emptying; Non-obese diabetic mice;
D O I：
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中图分类号：
学科分类号：
摘要：
Gastric emptying was measured in female non-obese diabetic (NOD) mice with a duration of diabetes of 28–35 days. As controls, age- and sex-matched BLAB/cJ mice were used. Gastric emptying of diabetic mice was significantly slower than that of controls. The faeces weight and water content were significantly higher in diabetic mice than controls. The endocrine cells known to correlate with gastric emptying, namely secretin, serotonin, petide YY (PYY) and enteroglucagon cells, were identified by immunocytochemistry and quantified by computer image analysis. The densities of duodenal secretin, serotonin and colonic PYY cells in NOD mice were significantly higher than that of control mice. Changes in these three endocrine cell types may play a role in delayed gastric emptying and in the manifestation of diarrhoea in this animal model of human diabetes type 1.
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页码：139 / 144
页数：5
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