Molecular Bases of Osteoporosis in HIV: The Role of the Virus and Antiretroviral Therapy

被引：0
|
作者：
D. Gibellini
M. Borderi
E. Vanino
A. Clò
S. Morini
L. Calza
M. C. Re
Pl. Viale
机构：
[1] University of Bologna,Department of Haematology and Oncological Sciences, Microbiology Section
[2] University of Bologna,Department of Internal Medicine, Aging and Nephrology, Infectious Diseases Section
来源：
Clinical Reviews in Bone and Mineral Metabolism | 2012年 / 10卷 / 4期
关键词：
HIV; Bone; Osteopenia/osteoporosis; Virus; Antiretrovirals;
D O I：
10.1007/s12018-012-9133-y
中图分类号：
学科分类号：
摘要：
In addition to immune system, HIV infection can determine the onset of functional dysfunctions of several organs and tissues such as central nervous system, cardiovascular system, kidney, and bone. It is noteworthy that HIV-infected individuals show an increased risk of bone mass loss with subsequent osteopenia and osteoporosis development. Interestingly, antiretroviral therapy is not able to tackle the bone derangement but, on the contrary, it can induce a progressive bone mass loss, especially when specific antiretroviral drugs are used. In this report, we summarized the HIV and antiretroviral-related mechanisms involved in the osteopenia and osteoporosis induction.
引用
收藏
页码：236 / 245
页数：9
相关论文
共 50 条
  • [1] Molecular Bases of Osteoporosis in HIV: The Role of the Virus and Antiretroviral Therapy
    Gibellini, D.
    Borderi, M.
    Vanino, E.
    Clo, A.
    Morini, S.
    Calza, L.
    Re, M. C.
    Viale, Pl.
    CLINICAL REVIEWS IN BONE AND MINERAL METABOLISM, 2012, 10 (04): : 236 - 245
  • [2] Role of antiretroviral therapy and HIV infection in atherosclerosis
    Hsue, Priscilla Y.
    Hunt, Peter W.
    Martin, Jeffrey N.
    Schnell, Amanda
    Kalapus, S. Craig
    Deeks, Steven G.
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2008, 51 (10) : A190 - A190
  • [3] HIV and Accelerated Atheroprogression: Role of Antiretroviral Therapy
    Di Biagio, Antonio
    Del Bono, Valerio
    Rosso, Raffaella
    Viscoli, Claudio
    CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 2012, 13 (01) : 88 - 96
  • [4] The Role of HIV and Antiretroviral Therapy in Bone Disease
    Gutierrez, Felix
    Masia, Mar
    AIDS REVIEWS, 2011, 13 (02) : 109 - 118
  • [5] Antiretroviral therapy and HIV/hepatitis B virus coinfection
    Benhamou, Y
    CLINICAL INFECTIOUS DISEASES, 2004, 38 : S98 - S103
  • [6] Molecular assays for monitoring HIV infection and antiretroviral therapy
    Wittek, Miriam
    Stuermer, Martin
    Doerr, Hans Wilhelm
    Berger, Annemarie
    EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2007, 7 (03) : 237 - 246
  • [7] The role of antiretroviral therapy in the management of HIV infection in women
    Mofenson, LM
    CLINICAL OBSTETRICS AND GYNECOLOGY, 1996, 39 (02): : 361 - 385
  • [8] The role of adherence to antiretroviral therapy in the management of HIV infection
    Conway, Brian
    JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2007, 45 : S14 - S18
  • [9] Role of HIV and Antiretroviral Therapy on the Expression of Placental Transporters in Women with HIV
    Kojovic, Dea
    Ghoneim, Ragia H.
    Serghides, Lena
    Piquette-Miller, Micheline
    AAPS JOURNAL, 2020, 22 (06):
  • [10] Role of HIV and Antiretroviral Therapy on the Expression of Placental Transporters in Women with HIV
    Dea Kojovic
    Ragia H. Ghoneim
    Lena Serghides
    Micheline Piquette-Miller
    The AAPS Journal, 22
12345