Vascular ATGL-dependent lipolysis and the activation of cPLA2–PGI2 pathway protect against postprandial endothelial dysfunction

被引：0
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作者：
M. Sternak
M. Stojak
T. Banasik
A. Kij
A. Bar
M. Z. Pacia
K. Wojnar-Lason
N. Chorazy
T. Mohaissen
B. Marczyk
I. Czyzynska-Cichon
Z. Berkimbayeva
A. Mika
S. Chlopicki
机构：
[1] Jagiellonian University,Jagiellonian Centre for Experimental Therapeutics (JCET)
[2] Jagiellonian University,Medical College, Chair of Pharmacology
[3] Jagiellonian University,Doctoral School of Exact and Natural Sciences
[4] University of Gdansk,Department of Environmental Analysis, Faculty of Chemistry
[5] Medical University of Gdansk,Department of Pharmaceutical Biochemistry
来源：
Cellular and Molecular Life Sciences | 2024年 / 81卷
关键词：
Lipid droplets; Lipolysis; Endothelium; Endothelial-induced vasodilation; Atglistatin; ATGL;
D O I：
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摘要：
Adipose triglyceride lipase (ATGL) is involved in lipolysis and displays a detrimental pathophysiological role in cardio-metabolic diseases. However, the organo-protective effects of ATGL-induced lipolysis were also suggested. The aim of this work was to characterize the function of lipid droplets (LDs) and ATGL-induced lipolysis in the regulation of endothelial function. ATGL-dependent LDs hydrolysis and cytosolic phospholipase A2 (cPLA2)-derived eicosanoids production were studied in the aorta, endothelial and smooth muscle cells exposed to exogenous oleic acid (OA) or arachidonic acid (AA). Functional effects of ATGL-dependent lipolysis and subsequent activation of cPLA2/PGI2 pathway were also studied in vivo in relation to postprandial endothelial dysfunction.
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