Selectivity to amyloid-β precursor protein cleavage provides hope against Alzheimer's

被引：0

作者：

Taisuke Tomita

Philip C Wong

机构：

[1] Graduate School of Pharmaceutical Science,Department of Neuropathology and Neuroscience

[2] The University of Tokyo,Departments of Pathology and Neuroscience

[3] The Johns Hopkins University School of Medicine,undefined

来源：

Alzheimer's Research & Therapy | / 3卷

关键词：

Notch Signaling; Notch Target Gene; Skin Cancer Risk; Elan Pharmaceutical; Strong Experimental Support;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Toward development of a safe and effective treatment for Alzheimer's disease, Elan Pharmaceuticals reported a novel γ-secretase inhibitor that specifically targets the cleavage of amyloid-β precursor protein, opening the way to design of substrate-specific γ-secretase inhibitors that would reduce the amyloid burden without significant adverse events.

引用

共 50 条

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