Molecular remission in adult T cell leukemia after autologous CD34+ peripheral blood stem cell transplantation

被引：0
|
作者：
M Nakane
K Ohashi
Y Sato
A Moriya
T Inoue
S Mori
S Tanikawa
H Akiyama
Y Maeda
T Sasaki
K Karasawa
Y Okuyama
K Hiruma
H Sakamaki
机构：
[1] Bone Marrow Transplantation Team,
[2] Tokyo Metropolitan Komagome Hospital,undefined
来源：
Bone Marrow Transplantation | 1999年 / 24卷
关键词：
CD34 selection; ATLL; inverse polymerase chain reaction; minimum residual disease;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
This report describes a patient with acute-type adult T cell leukemia/lymphoma (ATLL) successfully treated by autologous CD34+ peripheral blood stem cell transplantation after fractionated total body irradiation and high-dose cytarabine and cyclophosphamide. A newly established inverse polymerase chain reaction method was used to demonstrate the disappearance of ATLL clonal cells. The patient achieved a sustained molecular remission after transplantation, but died from opportunistic infection 4 months after transplantation. Thus, autologous CD34+ peripheral blood stem cell transplantation is promising for this type of malignancy. However, a prudent clinical attitude toward immunological fragility after transplantation is needed for better outcome.
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页码：219 / 221
页数：2
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