Influence of transplantation regimen on prognostic significance of high-level minimal residual disease before allogeneic stem cell transplantation in children with ALL

被引：0
|
作者：
M Schneider
K Hettinger
S Matthes-Martin
M Konrad
C Peters
H Gadner
ER Panzer-Grümayer
机构：
[1] Children's Cancer Research Institute and St Anna Kinderspital,
来源：
Bone Marrow Transplantation | 2001年 / 28卷
关键词：
childhood ALL; bone marrow transplantation; minimal residual disease;
D O I：
暂无
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学科分类号：
摘要：
High MRD levels before transplantation in children receiving T cell-depleted unrelated grafts for relapsed ALL were associated with a 100% relapse risk. We report on two children with relapsed ALL who underwent non T cell-depleted BMT from unrelated donors. Despite a high residual tumor load pre- transplant and the occurrence of only aGVHD grade I, they are still in second complete remission 2.7 and 5.2 years after transplantation, respectively. Thus, we propose that the transplant regimens influence the prognostic significance of high MRD levels pre-BMT.
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页码：1087 / 1089
页数：2
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