Antibacterial glycopeptide antibiotics (review)

被引：0
|
作者：
Preobrazhenskaya M.N. [1 ]
Miroshnikova O.V. [1 ]
Pavlov A.Yu. [1 ]
Olsuf'eva E.N. [1 ]
机构：
[1] Institute of Research into New Antibiotics, RAMN, Moscow
来源：
Chemistry of Heterocyclic Compounds | 1998年 / 34卷 / 12期
关键词：
Organic Chemistry; Acid Composition; Chemical Modification; Amino Acid Composition; Model Compound;
D O I：
10.1007/BF02317806
中图分类号：
学科分类号：
摘要：
The structures of the most important antibacterial glycopeptide antibiotics and the mechanisms of their activity and resistance to them are examined. Researches on the total synthesis of antibiotics and model compounds are discussed. The chemical modification of antibiotics (changing the amino acid composition) and also the modification of fragments of the molecule that do not take part in interaction with the target but make it possible to overcome the resistance of bacteria to antibiotics of this group are discussed. © 1999 Kluwer Academic/Plenum Publishers.
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页码：1359 / 1381
页数：22
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