Relationship between serum uric acid in early pregnancy and gestational diabetes mellitus: a prospective cohort study

被引：0
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作者：
Yanbei Duo
Shuoning Song
Yuemei Zhang
Xiaolin Qiao
Jiyu Xu
Jing Zhang
Zhenyao Peng
Yan Chen
Xiaorui Nie
Qiujin Sun
Xianchun Yang
Ailing Wang
Wei Sun
Yong Fu
Yingyue Dong
Zechun Lu
Tao Yuan
Weigang Zhao
机构：
[1] Peking Union Medical College Hospital,Department of Endocrinology, Key Laboratory of Endocrinology of Ministry of Health
[2] Chinese Academy of Medical Science and Peking Union Medical College,Department of Obstetrics
[3] Haidian District Maternal and Child Health Care Hospital,Department of Obstetrics
[4] Beijing Chaoyang District Maternal and Child Health Care Hospital,Core Facility of Instrument, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine
[5] Peking Union Medical College,Department of Laboratory
[6] Haidian District Maternal and Child Health Care Hospital,Department of Dean’s Office
[7] Haidian District Maternal and Child Health Care Hospital,Department of Clinical Laboratory
[8] Beijing Chaoyang District Maternal and Child Health Care Hospital,undefined
[9] National Center for Women and Children’s Health,undefined
[10] China CDC,undefined
来源：
Endocrine | 2024年 / 83卷
关键词：
Serum uric acid; Early pregnancy; Gestational diabetes mellitus; Risk factor; Prospective study;
D O I：
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学科分类号：
摘要：
The levels of serum uric acid (UA) and creatinine in the first trimester of pregnant women were significantly lower than healthy non-pregnant women, probably because of the increase of glomerular filtration.Serum UA concentration in the first trimester was significantly higher in women with gestational diabetes mellitus (GDM) than in women with normal glucose tolerance (NGT). The association of serum UA in the first trimester and GDM were observed when serum UA was above 240 μmol/l, and the association was stronger in women aged over 35 years old and preBMI ≥ 24 kg/m2.To prevent GDM, healthy lifestyle intervention should be taken since early pregnancy to control serum UA concentration, especially in older and heavier pregnant women.
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页码：636 / 647
页数：11
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