Effects of leukotrienes and prostaglandins on cochlear blood flow in the chinchilla

被引：0

作者：

C. -K. Rhee

Y. -S. Park

T. T. K. Jung

C. -I. Park

机构：

[1] Department of Otolaryngology-Head and Neck Surgery,

[2] Dankook University College of Medicine,undefined

[3] San 29,undefined

[4] Anseo-Dong,undefined

[5] Cheonan,undefined

[6] Chungnam-Do,undefined

[7] Korea 330–714,undefined

[8] Department of Otolaryngology,undefined

[9] Catholic University College of Medicine,undefined

[10] Seoul,undefined

[11] Korea,undefined

[12] Department of Otolaryngology-Head and Neck Surgery,undefined

[13] Loma Linda University School of Medicine and Jerry L. Pettis Memorial Veterans Medical Center,undefined

[14] Loma Linda,undefined

[15] California,undefined

[16] USA,undefined

[17] Department of Otolaryngology,undefined

[18] Chungnam National University College of Medicine,undefined

[19] Taejon,undefined

[20] Korea,undefined

来源：

European Archives of Oto-Rhino-Laryngology | 1999年 / 256卷

关键词：

Key words Cochlear blood flow; Prostaglandin; Leukotriene; Laser Doppler flowmeter;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Prostaglandins (PGs) such as PGE2 and PGI2 are vasodilators, and leukotrienes (LTs) such as LTB4 and LTC4 are vasoconstrictors. Our previous studies have shown that salicylate ototoxicity is associated with decreased levels of PGs and increased levels of LTs. We hypothesized that vasodilating PGs increase cochlear blood flow and vasoconstricting LTs decrease cochlear blood flow. PGE2, Iloprost (a PGI2 analog), LTB4, and LTC4 were applied to the round window membranes of chinchillas and cochlear blood flow was measured with a laser Doppler flowmeter. PGE2 increased cochlear blood flow, while LTC4 decreased cochlear blood flow. This findings show that vasodilating PGs may have therapeutic implications for sensorineural hearing loss and/or vertigo by increasing cochlear blood flow. Vasoconstricting LTs may cause hearing loss by decreasing cochlear blood flow.

引用

页码：479 / 483

页数：4

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