N-methyl-d-aspartate receptor subunit mRNA expression in human retinal ganglion cells

被引：0

作者：

W. A. Lagrèze

Melanie Darstein

Thomas J. Feuerstein

T. Otto

G. Bernhard Landwehrmeyer

机构：

[1] Department of Ophthalmology,

[2] Albert-Ludwigs Universität Freiburg,undefined

[3] Killianstr. 5,undefined

[4] 79102 Freiburg,undefined

[5] Germany e-mail: lagreze@ukl.uni-freiburg.de Tel.: +49–761–2704001 Fax: +49–761–2704114,undefined

[6] Department of Neurology,undefined

[7] Albert-Ludwigs Universität Freiburg,undefined

[8] Killianstr. 5,undefined

[9] 79102 Freiburg,undefined

[10] Germany,undefined

来源：

Graefe's Archive for Clinical and Experimental Ophthalmology | 2000年 / 238卷

关键词：

mRNA Expression; Retina; Ganglion Cell; Cell Loss; Retinal Ganglion Cell;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Porpose: To determine the expression of mRNA coding for different N-methyl-d-aspartate receptor (NR) subunits in the human retina.Methods: In five human eyes the distribution of NR subunit mRNA was determined by in situ hybridization using 35S-labeled cRNA probes. In 100 consecutive retinal ganglion cells of each eye the level of mRNA expression of the different NR subunits was qualitatively graded. Results: Ninety-three percent of retinal ganglion cells expressed mRNA coding for NR1, 9% for NR2A, 28% for NR2B, 86% for NR2C, and 84% for NR2D. The pattern of expression did not vary among the five eyes.Conclusion: These data establish distinct expression profiles of NR subunits in human retinal ganglion cells and suggest the development of specific NR ligands to reduce excitotoxic retinal ganglion cell loss.

引用

页码：486 / 490

页数：4

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