Inability of NS1 protein from an H5N1 influenza virus to activate PI3K/Akt signaling pathway correlates to the enhanced virus replication upon PI3K inhibition

被引：0
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作者：
Weizhong Li
Gefei Wang
Heng Zhang
Yanqin Shen
Jianping Dai
Liqi Wu
Jianxiang Zhou
Zhiwu Jiang
Kangsheng Li
机构：
[1] Shantou University Medical College,Department of Microbiology and Immunology, Key Immunopathology Laboratory of Guangdong Province
[2] University of Maryland,Department of Veterinary Medicine
来源：
Veterinary Research | / 43卷
关键词：
Influenza; Influenza Virus; H5N1 Virus; MDCK Cell; Amino Acid Mutation;
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摘要：
Phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway, activated during influenza A virus infection, can promote viral replication via multiple mechanisms. Direct binding of NS1 protein to p85β subunit of PI3K is required for activation of PI3K/Akt signaling. Binding and subsequent activation of PI3K is believed to be a conserved character of influenza A virus NS1 protein. Sequence variation of NS1 proteins in different influenza A viruses led us to investigate possible deviation from the conservativeness.
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