Growth hormone and aging

被引：0
|
作者：
Andrzej Bartke
机构：
[1] Southern Illinois University School of Medicine,Department of Physiology
来源：
Endocrine | 1998年 / 8卷
关键词：
Growth hormone; aging; body size; life-span;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Although age-related decline in plasma growth hormone (GH) levels is well documented, the possible role of GH in the control of aging is controversial. Overexpression of GH in transgenic mice is associated with reduced life expectancy and numerous symptoms of premature aging. Ames dwarf mice with hereditary GH, prolactin, and thyrotropin deficiency live much longer than their normal siblings. In contrast to these indications that GH may accelerate aging, some physiological changes in the elderly resemble symptoms of GH deficiency and can be corrected by GH replacement.
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页码：103 / 108
页数：5
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