Molecular genetic studies of familial hypertrophic cardiomyopathy

被引：0
|
作者：
C.E. Seidman
J.G. Seidman
机构：
[1] Dept. of Genetics,
[2] Harvard Medical School,undefined
[3] Alpert Building Room 533,undefined
[4] 200 Longwood Ave,undefined
[5] Boston,undefined
[6] MA 02115,undefined
[7] USA,undefined
来源：
Basic Research in Cardiology | 1998年 / 93卷 / Suppl 3期
关键词：
Cardiomyopathy; Genetic Study; Murine Model; Patient Management; Disease Gene;
D O I：
10.1007/s003950050196
中图分类号：
学科分类号：
摘要：
Molecular genetic studies of FHC have defined this as disease of the sarcomere. Multiple different mutations in six disease genes, which appear to act through a dominant negative mechanism, have been identified. A relevant murine model of human FHC has been developed. Assessment of the influences that genetics and environment play in disease expression may in the future help direct patient management and assist in the development of novel therapeutics.
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页码：s013 / s016
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