Adaptive immunity to the obligate intracellular pathogen Coxiella burnetii

被引：0
|
作者：
Jeffrey G. Shannon
Robert A. Heinzen
机构：
[1] NIAID,Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories
[2] NIH,undefined
来源：
Immunologic Research | 2009年 / 43卷
关键词：
Adaptive immunity; Cell-mediated immunity; Antibody-mediated immunity; Dendritic cell; Vaccine;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Coxiella burnetii is an obligate intracellular bacterial pathogen that causes the zoonosis Q fever. While an effective whole-cell vaccine (WCV) against Q fever exists, the vaccine has limitations in being highly reactogenic in sensitized individuals. Thus, a safe and effective vaccine based on recombinant protein antigen (Ag) is desirable. To achieve this goal, a better understanding of the host response to primary infection and the precise mechanisms involved in protective immunity to C. burnetii are needed. This review summarizes our current understanding of adaptive immunity to C. burnetii with a focus on recent developments in the field.
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页码：138 / 148
页数：10
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