N-substituted tetrahydro-1,3-oxazines and -oxazolidines. 2. Nitration of N-(ω-acylamino-β,β-dinitroalkyl)tetrahydro-1,3-oxazines and -oxazolidines

被引：0
|
作者：
A. G. Korepin
P. V. Galkin
E. K. Perepelkina
N. M. Glushakova
I. L. Eremenko
L. T. Eremenko
机构：
[1] Russian Academy of Sciences,Institute of Problems of Chemical Physics
[2] Russian Academy of Sciences,N. S. Kurnakov Institute of General and Inorganic Chemistry
来源：
Russian Chemical Bulletin | 2009年 / 58卷
关键词：
C- and O-aminomethylation; (acylamino)dinitroalkanes; -(ω-acylamino-β,β-dinitroalkyl)tetrahydro-1,3-oxazines and ; -(ω-acylamino-β,β-dinitroalkyl)oxazolidines; nitration; O-nitrates; acute toxicity; cardioprotection;
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学科分类号：
摘要：
Nitration of N-(ω-acylamino0-β,β-dinitroalkyl)tetrahydro-1,3-oxazines and N-(ω-acylamino-β,β-dinitroalkyl)oxazolidines resulted in O-nitrates bearing amide, dinitromethylene, and nitroamine groups. It was found that nitration can be accompanied by N-hydroxymethylation of the amide group. Three nitrates synthesized were tested for, and exhibited good level of, cardioprotection.
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页码：2103 / 2108
页数：5
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