GPCR drug discovery: integrating solution NMR data with crystal and cryo-EM structures

被引：0

作者：

Ichio Shimada

Takumi Ueda

Yutaka Kofuku

Matthew T. Eddy

Kurt Wüthrich

机构：

[1] Graduate School of Pharmaceutical Sciences,Department of Integrative Structural and Computational Biology

[2] The University of Tokyo,Departments of Biological Sciences and Chemistry

[3] Hongo,undefined

[4] Skaggs Institute of Chemical Biology,undefined

[5] The Scripps Research Institute,undefined

[6] Bridge Institute,undefined

[7] USC Michelson Center,undefined

[8] University of Southern California,undefined

[9] Skaggs Institute of Chemical Biology,undefined

[10] The Scripps Research Institute,undefined

[11] Present address: Department of Chemistry,undefined

[12] University of Florida,undefined

[13] Gainesville,undefined

[14] FL,undefined

[15] USA.,undefined

来源：

Nature Reviews Drug Discovery | 2019年 / 18卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Determination of the crystal structures of more than 50 human G protein-coupled receptors (GPCRs) during the past decade has provided a platform for structure-based drug design for this key target class, which is being augmented with cryo-electron microscopy (cryo-EM) structures and nuclear magnetic resonance (NMR) spectroscopy studies of dynamic features. This Review describes the application of NMR techniques to GPCRs and projects where crystal and/or cryo-EM structures have been complemented with NMR studies and discusses the impact of this integrative approach on GPCR biology and drug discovery.

引用

页码：59 / 82

页数：23

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