Neoadjuvant clinical trials provide a window of opportunity for cancer drug discovery

被引：0

作者：

Thomas U. Marron

Matthew D. Galsky

Bachir Taouli

Maria Isabel Fiel

Stephen Ward

Edward Kim

David Yankelevitz

Deborah Doroshow

Emma Guttman-Yassky

Benjamin Ungar

Saurabh Mehandru

Benjamin J. Golas

Daniel Labow

John Sfakianos

Sujit S. Nair

Dimple Chakravarty

Michael Buckstein

Xiaoyu Song

Effi Kenigsberg

Sacha Gnjatic

Brian D. Brown

Joseph Sparano

Ashutosh Tewari

Myron Schwartz

Nina Bhardwaj

Miriam Merad

机构：

[1] Icahn School of Medicine at Mount Sinai,The neoAdjuvant Research Group to Evaluate Therapeutics (TARGET)

[2] Icahn School of Medicine at Mount Sinai,Immunotherapy and Novel TargEt Research Across Clinical Teams (INTERACT)

[3] Icahn School of Medicine at Mount Sinai,Early Phase Trials Unit, Tisch Cancer Institute

[4] Icahn School of Medicine at Mount Sinai,Tisch Cancer Institute

[5] Icahn School of Medicine at Mount Sinai,Precision Immunology Institute

[6] Icahn School of Medicine at Mount Sinai,Division of Hematology and Medical Oncology

[7] Icahn School of Medicine at Mount Sinai,Center for Thoracic Oncology, Tisch Cancer Institute

[8] Icahn School of Medicine at Mount Sinai,Center of Excellence for Liver and Bile Duct Cancer

[9] Icahn School of Medicine at Mount Sinai,Liver Cancer Program, Division of Liver Diseases and RM Transplant Institute

[10] Icahn School of Medicine at Mount Sinai,Department of Urology

[11] Molecular and Interventional Radiology,Department of Diagnostic

[12] Icahn School of Medicine at Mount Sinai,BioMedical Engineering and Imaging Institute

[13] Icahn School of Medicine at Mount Sinai,Department of Pathology

[14] Icahn School of Medicine at Mount Sinai,Division of Interventional Radiology

[15] Icahn School of Medicine at Mount Sinai,Department of Dermatology

[16] Icahn School of Medicine at Mount Sinai,Division of Gastroenterology

[17] Icahn School of Medicine at Mount Sinai,Division of Surgical Oncology

[18] Icahn School of Medicine at Mount Sinai,Department of Radiation Oncology

[19] Icahn School of Medicine at Mount Sinai,Department of Population Health Science and Policy

[20] Icahn School of Medicine at Mount Sinai,Department of Oncological Sciences

[21] Icahn School of Medicine at Mount Sinai,Department of Genomics and Genetics

[22] Icahn School of Medicine at Mount Sinai,undefined

来源：

Nature Medicine | 2022年 / 28卷

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中图分类号：

学科分类号：

摘要：

Window-of-opportunity trials, during which patients receive short-duration pre-surgical therapies, provide a platform for understanding the therapies’ mechanisms of action, but will require a paradigm shift in trial design, specimen collection and analysis.

引用

页码：626 / 629

页数：3

共 50 条

[1] Neoadjuvant clinical trials provide a window of opportunity for cancer drug discovery
Marron, Thomas U.
Galsky, Matthew D.
Taouli, Bachir
Fiel, Maria Isabel
Ward, Stephen
Kim, Edward
Yankelevitz, David
Doroshow, Deborah
Guttman, Emma
Ungar, Benjamin
Mehandru, Saurabh
Golas, Benjamin J.
Labow, Daniel
Sfakianos, John
Nair, Sujit S.
Chakravarty, Dimple
Buckstein, Michael
Song, Xiaoyu
Kenigsberg, Effi
Gnjatic, Sacha
Brown, Brian D.
Sparano, Joseph
Tewari, Ashutosh
Schwartz, Myron
Bhardwaj, Nina
Merad, Miriam
[J]. NATURE MEDICINE, 2022, 28 (04) : 626 - 629
[2] Author Correction: Neoadjuvant clinical trials provide a window of opportunity for cancer drug discovery
Thomas U. Marron
Matthew D. Galsky
Bachir Taouli
Maria Isabel Fiel
Stephen Ward
Edward Kim
David Yankelevitz
Deborah Doroshow
Emma Guttman-Yassky
Benjamin Ungar
Saurabh Mehandru
Benjamin J. Golas
Daniel Labow
John Sfakianos
Sujit S. Nair
Dimple Chakravarty
Michael Buckstein
Xiaoyu Song
Effi Kenigsberg
Sacha Gnjatic
Brian D. Brown
Joseph Sparano
Ashutosh Tewari
Myron Schwartz
Nina Bhardwaj
Miriam Merad
[J]. Nature Medicine, 2022, 28 : 1723 - 1723
[3] Neoadjuvant clinical trials provide a window of opportunity for cancer drug discovery (vol 28, pg 626, 2022)
Marron, Thomas U.
Galsky, Matthew D.
Taouli, Bachir
Fiel, Maria Isabel
Ward, Stephen
Kim, Edward
Yankelevitz, David
Doroshow, Deborah
Guttman-Yassky, Emma
Ungar, Benjamin
Mehandru, Saurabh
Golas, Benjamin J.
Labow, Daniel
Sfakianos, John
Nair, Sujit S.
Chakravarty, Dimple
Buckstein, Michael
Song, Xiaoyu
Kenigsberg, Effi
Gnjatic, Sacha
Brown, Brian D.
Sparano, Joseph
Tewari, Ashutosh
Schwartz, Myron
Bhardwaj, Nina
Merad, Miriam
[J]. NATURE MEDICINE, 2022, 28 (08) : 1723 - 1723
[4] Window of Opportunity trials for biomarker discovery in breast cancer
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[J]. CURRENT OPINION IN ONCOLOGY, 2019, 31 (06) : 486 - 492
[5] Challenges of Neoadjuvant Window of Opportunity Trials
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[J]. JOURNAL OF THORACIC ONCOLOGY, 2009, 4 (09) : S44 - S44
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[J]. BREAST CANCER RESEARCH AND TREATMENT, 2022, 194 (01) : 171 - 178
[10] Patient perspectives on window of opportunity clinical trials in early-stage breast cancer
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