Comprehensive genomic profiling in routine clinical practice leads to a low rate of benefit from genotype-directed therapy

被引：0
|
作者：
Talal Hilal
Mary Nakazawa
Jacob Hodskins
John L. Villano
Aju Mathew
Guarav Goel
Lars Wagner
Susanne M. Arnold
Philip DeSimone
Lowell B. Anthony
Peter J. Hosein
机构：
[1] Division of Hematology and Medical Oncology,Division of Medical Oncology
[2] Mayo Clinic,Department of Medicine, Division of Hematology/Oncology
[3] University of Kentucky College of Medicine,Hematology/Oncology
[4] University of Kentucky,undefined
[5] Markey Cancer Center,undefined
[6] University of Pittsburgh Cancer Institute,undefined
[7] University of Miami School of Medicine and Sylvester Comprehensive Cancer Center,undefined
来源：
BMC Cancer | / 17卷
关键词：
Genotype-directed therapy; Profiling; Genomics; Cancer therapeutics;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 13 条
  • [1] Comprehensive genomic profiling in routine clinical practice leads to a low rate of benefit from genotype-directed therapy
    Hilal, Talal
    Nakazawa, Mary
    Hodskins, Jacob
    Villano, John L.
    Mathew, Aju
    Goel, Guarav
    Wagner, Lars
    Arnold, Susanne M.
    DeSimone, Philip
    Anthony, Lowell B.
    Hosein, Peter J.
    BMC CANCER, 2017, 17
  • [2] Prognostic benefit of comprehensive genomic profiling in clinical practice remains uncertain
    Ikegami, Masachika
    CANCER SCIENCE, 2023, 114 (07) : 3053 - 3055
  • [3] Comprehensive Genomic Profiling of Chronic Myelomonocytic Leukemia in Routine Clinical Practice - MSKCC Experience
    Pal, Prodipto
    Dogan, Ahmet
    Arcila, Maria
    Rampal, Raaju
    Wang, Lu
    Chiu, April
    MODERN PATHOLOGY, 2015, 28 : 371A - 371A
  • [4] Comprehensive Genomic Profiling of Chronic Myelomonocytic Leukemia in Routine Clinical Practice - MSKCC Experience
    Pal, Prodipto
    Dogan, Ahmet
    Arcila, Maria
    Rampal, Raajit
    Wang, Lu
    Chiu, April
    LABORATORY INVESTIGATION, 2015, 95 : 371A - 371A
  • [5] The acceleration of adoption of tumor profiling into routine clinical practice: An insight from review of the literature and the case for comprehensive profiling.
    Conforti, Rosa
    Russel, Kenneth
    Lefevre, Olivier
    Voss, Andreas
    Khayat, David
    JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (15)
  • [6] Integrating multiplex and next generation sequencing (NGS) platforms in routine molecular profiling of metastatic breast cancer (MBC) patients (pts): Trends for enrollment in genotype-directed clinical trials (GDTs)
    Oliveira, M.
    Dienstmann, R.
    Bellet, M.
    Perez-Garcia, J. M.
    Gomez, P.
    Munoz-Couselo, E.
    Vidal, M.
    Ortega, V.
    Zamora, E.
    Soberino, J.
    Meire, A.
    Nuciforo, P.
    Vivancos, A.
    Cortes, J.
    Saura, C.
    CANCER RESEARCH, 2016, 76
  • [7] COMPREHENSIVE GENOMIC PROFILING (CGP) OF PEDIATRIC GLIOMAS REVEALS A HIGH FREQUENCY OF CLINICALLY RELEVANT GENOMIC ALTERATIONS (CRGA) ASSOCIATED WITH BENEFIT FROM TARGETED THERAPY
    Chalmers, Zachary R.
    Ali, Siraj M.
    Frampton, Garrett M.
    Chmielecki, Juliann
    Palma, Norma A.
    Elvin, Julia A.
    Johnson, Adrienne
    Yelensky, Roman
    Ross, Jeffery S.
    Stephens, Phillip J.
    Miller, Vincent A.
    Waanders, Angela J.
    Crawford, John
    NEURO-ONCOLOGY, 2015, 17 : 7 - 8
  • [8] Comprehensive Genomic Profiling of Lung Adenocarcinoma Identifies Patients with Genomic Alterations beyond Clinical Testing Guidelines Who May Benefit from Enrollment in Mechanism Driven Clinical Trials
    Albacker, Lee
    Chmielecki, Juliann
    Elvin, Julia A.
    Vergilio, Jo-Anne
    Miller, Vincent A.
    Stephens, Philip J.
    Ross, Jeffrey S.
    Ali, Siraj M.
    Suh, James
    MODERN PATHOLOGY, 2016, 29 : 451A - 451A
  • [9] Comprehensive Genomic Profiling of Lung Adenocarcinoma Identifies Patients with Genomic Alterations beyond Clinical Testing Guidelines Who May Benefit from Enrollment in Mechanism Driven Clinical Trials
    Albacker, Lee
    Chmielecki, Juliann
    Elvin, Julia A.
    Vergilio, Jo-Anne
    Miller, Vincent A.
    Stephens, Philip J.
    Ross, Jeffrey S.
    Ali, Siraj M.
    Suh, James
    LABORATORY INVESTIGATION, 2016, 96 : 451A - 451A
  • [10] Correlates of clinical benefit from immunotherapy and targeted therapy in metastatic renal cell carcinoma: comprehensive genomic and transcriptomic analysis
    Dizman, Nazli
    Lyou, Yung
    Salgia, Nicholas
    Bergerot, Paulo Gustavo
    Hsu, JoAnn
    Enriquez, Daniel
    Izatt, Tyler
    Trent, Jeffrey M.
    Byron, Sara
    Pal, Sumanta
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2020, 8 (02)
12