The current article primarily focuses on the peristaltic flow of hybrid nanofluid containing (Cu) and (Ag) as nanoparticles and blood is considered as a carrier fluid in a symmetric channel. The fundamental equations such as momentum, energy, and concentration are mathematically modeled under the consideration of mixed convection, thermal radiation, Joule heating, viscous dissipation, and heat sink/source effects. The effects of an inclined magnetic field are also added since it plays an essential role in blood flow through arteries. Heat source/sink effects are considered to maintain the homogeneous temperature to improve blood circulation. Moreover, the flow characteristics of homogeneous–heterogeneous reactions are also elaborated. To overcome the complexity of the mathematical system, an assumption of small Reynolds number (i.e., Re→0\documentclass[12pt]{minimal}
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\begin{document}$${\text{Re}}\, \to \,0$$\end{document}) and long-wavelength is utilized. Built-in numerical solver, i.e., ND-Solve is used to attain numerical results. The graphical influence of embedded parameters on flow quantities is graphically analyzed and discussed physically. The inclined magnetic field has an increasing impact on fluid velocity while reducing fluid temperature. The homogeneous/heterogeneous reaction parameters depict an opposite behavior on the chemical distribution of species (f(y)). For larger magnetic inclination angles (ξ)\documentclass[12pt]{minimal}
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\begin{document}$$(\xi )$$\end{document}, the size of the trapped bolus enhances.