Caspase 8: The killer you can't live without

被引：0
|
作者：
Philippe Juin
Gerard Evan
机构：
[1] UCSF Cancer Center,
来源：
Nature Medicine | 2000年 / 6卷
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摘要：
The proto-oncogene MYCN, a regulator of cell proliferation and cell death, is amplified in aggressive neuroblastomas, whereas expression of the apoptotic effector caspase 8 is suppressed. Understanding why this nervous system tumor should choose to up or down regulate these particular apoptotic factors may provide important information about oncogenesis and indicate new strategies for the treatment of neuroblastoma ( pages 529–535).
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页码：498 / 500
页数：2
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