Recent advances in the C(1)-functionalization of tetrahydroisoquinolines via multicomponent reactions

被引：0
|
作者：
Pavneet Kaur
Rakesh Kumar
机构：
[1] Central University of Punjab,Laboratory of Organic Chemistry, Department of Chemistry
来源：
Chemistry of Heterocyclic Compounds | 2020年 / 56卷
关键词：
heterocyclic compounds; iminium ion; tetrahydroisoquinoline; C(1)-functionalization; multicomponent reactions;
D O I：
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摘要：
1,2,3,4-Tetrahydroisoquinoline is an important structural motif of various natural products and therapeutic lead compounds. In recent years, considerable research interest has been witnessed toward synthesis of its C(1)-substituted derivatives, since they can act as precursors for various alkaloids displaying multifarious biological activities. This minireview offers short and non-exhaustive epitome of various multicomponent reactions for the C(1)-functionalization of 1,2,3,4-tetrahydroisoquinolines. In particular, reactions involving isomerization of iminium intermediate (exo/endo isomerization) are highlighted for the period of 2013–2019.
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页码：422 / 432
页数：10
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