PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

被引：0
|
作者：
Cheryl L. Day
Daniel E. Kaufmann
Photini Kiepiela
Julia A. Brown
Eshia S. Moodley
Sharon Reddy
Elizabeth W. Mackey
Joseph D. Miller
Alasdair J. Leslie
Chantal DePierres
Zenele Mncube
Jaikumar Duraiswamy
Baogong Zhu
Quentin Eichbaum
Marcus Altfeld
E. John Wherry
Hoosen M. Coovadia
Philip J. R. Goulder
Paul Klenerman
Rafi Ahmed
Gordon J. Freeman
Bruce D. Walker
机构：
[1] Doris Duke Medical Research Institute,HIV Pathogenesis Programme
[2] University of KwaZulu Natal,Partners AIDS Research Center
[3] Massachusetts General Hospital and Division of AIDS,Nuffield Department of Medicine
[4] Harvard Medical School,Department of Medical Oncology
[5] The Peter Medawar Building for Pathogen Research,Emory Vaccine Center and Department of Microbiology & Immunology
[6] Oxford University,Immunology Program
[7] Dana-Farber Cancer Institute,undefined
[8] Department of Medicine,undefined
[9] Harvard Medical School,undefined
[10] Emory University School of Medicine,undefined
[11] Immunology,undefined
[12] Emory University School of Medicine,undefined
[13] The Wistar Institute,undefined
[14] Howard Hughes Medical Institute,undefined
来源：
Nature | 2006年 / 443卷
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摘要：
Blocking a protein called PD-1 (programmed death 1) might provide a way to boost the immune function of T cells crippled by HIV infection. A study published earlier this year showed that blocking of PD-1 function in virally infected mice could restore the function of exhausted T cells and help fight infection. Now the phenomenon has been found to occur in humans. The T cells in HIV patients were found to have many more PD-1 receptors on their surface than is normal; the degree of PD-1 production correlates with markers of disease progression including the extent to which T cells are disabled and the levels of virus within the body. An antibody that blocks this receptor promotes the immune response to HIV in laboratory experiments, suggesting that a similar strategy might work to fight the disease in humans.
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页码：350 / 354
页数：4
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