The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa

被引：0

作者：

Se Eun Park

Duy Thanh Pham

Christine Boinett

Vanessa K. Wong

Gi Deok Pak

Ursula Panzner

Ligia Maria Cruz Espinoza

Vera von Kalckreuth

Justin Im

Heidi Schütt-Gerowitt

John A. Crump

Robert F. Breiman

Yaw Adu-Sarkodie

Ellis Owusu-Dabo

Raphaël Rakotozandrindrainy

Abdramane Bassiahi Soura

Abraham Aseffa

Nagla Gasmelseed

Karen H. Keddy

Jürgen May

Amy Gassama Sow

Peter Aaby

Holly M. Biggs

Julian T. Hertz

Joel M. Montgomery

Leonard Cosmas

Beatrice Olack

Barry Fields

Nimako Sarpong

Tsiriniaina Jean Luco Razafindrabe

Tiana Mirana Raminosoa

Leon Parfait Kabore

Emmanuel Sampo

Mekonnen Teferi

Biruk Yeshitela

Muna Ahmed El Tayeb

Arvinda Sooka

Christian G. Meyer

Ralf Krumkamp

Denise Myriam Dekker

Anna Jaeger

Sven Poppert

Adama Tall

Aissatou Niang

Morten Bjerregaard-Andersen

Sandra Valborg Løfberg

Hye Jin Seo

Hyon Jin Jeon

Jessica Fung Deerin

Jinkyung Park

机构：

[1] SNU Research Park,International Vaccine Institute

[2] 1 Gwanak-ro,The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme

[3] 1 Gwanak-gu,Centre for Tropical Medicine and Global Health

[4] Oxford University Clinical Research Unit,Centre for Genomic Pathogen Surveillance

[5] University of Oxford,Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust

[6] Old Road campus,Institute of Medical Microbiology

[7] Wellcome Genome Campus,Division of Infectious Diseases and International Health

[8] Hinxton,Duke Global Health Institute

[9] Cambridge Biomedical Campus,Centre for International Health

[10] Hills Road,Emory Global Health Institute

[11] University of Cologne,Kumasi Centre for Collaborative Research in Tropical Medicine

[12] Kilimanjaro Christian Medical Centre,Institut Supérieur des Sciences de la Population

[13] Duke University Medical Center,Faculty of Science

[14] Duke University,Faculty of Health Sciences

[15] University of Otago,German Center for Infection Research

[16] Centers for Disease Control and Prevention,Research Center for Vitamins and Vaccines

[17] Emory University,Institute of Tropical Medicine

[18] 1599 Clifton Road,Swiss Tropical and Public Health Institute

[19] NE,Division of Pediatric Infectious Diseases

[20] Kwame Nkrumah University of Science and Technology,Big Data Institute

[21] Kwame Nkrumah University of Science and Technology,Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute

[22] KCCR,The Department of Medicine

[23] UPO,undefined

[24] PMB,undefined

[25] KNUST,undefined

[26] University of Antananarivo,undefined

[27] University of Ouagadougou,undefined

[28] Armauer Hansen Research Institute,undefined

[29] Faculty of Medicine,undefined

[30] University of Gezira,undefined

[31] University of Hafr Al Batin,undefined

[32] Al Jamiah,undefined

[33] National Institute for Communicable Diseases,undefined

[34] University of the Witwatersrand,undefined

[35] Bernhard Nocht Institute for Tropical Medicine,undefined

[36] Hamburg-Borstel-Lübeck,undefined

[37] Institute Pasteur de Dakar,undefined

[38] Université Cheikh Anta Diop de Dakar,undefined

[39] Bandim Health Project,undefined

[40] Apartado,undefined

[41] Bandim Health Project,undefined

[42] Statens Serum Institut,undefined

[43] Kenya Medical Research Institute,undefined

[44] Schiphra Hospital,undefined

[45] Eberhard-Karls University Tübingen,undefined

[46] Geschwister-Scholl-Platz,undefined

[47] Duy Tan University,undefined

[48] 254 Nguyen Van Linh,undefined

[49] University of Basel,undefined

[50] Johns Hopkins Bloomberg School of Public Health,undefined

来源：

Nature Communications | / 9卷

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摘要：

There is paucity of data regarding the geographical distribution, incidence, and phylogenetics of multi-drug resistant (MDR) Salmonella Typhi in sub-Saharan Africa. Here we present a phylogenetic reconstruction of whole genome sequenced 249 contemporaneous S. Typhi isolated between 2008-2015 in 11 sub-Saharan African countries, in context of the 2,057 global S. Typhi genomic framework. Despite the broad genetic diversity, the majority of organisms (225/249; 90%) belong to only three genotypes, 4.3.1 (H58) (99/249; 40%), 3.1.1 (97/249; 39%), and 2.3.2 (29/249; 12%). Genotypes 4.3.1 and 3.1.1 are confined within East and West Africa, respectively. MDR phenotype is found in over 50% of organisms restricted within these dominant genotypes. High incidences of MDR S. Typhi are calculated in locations with a high burden of typhoid, specifically in children aged <15 years. Antimicrobial stewardship, MDR surveillance, and the introduction of typhoid conjugate vaccines will be critical for the control of MDR typhoid in Africa.

引用

共 50 条

[1] The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa
Park, Se Eun
Duy Thanh Pham
Boinett, Christine
Wong, Vanessa K.
Pak, Gi Deok
Panzner, Ursula
Espinoza, Ligia Maria Cruz
von Kalckreuth, Vera
Im, Justin
Schuett-Gerowitt, Heidi
Crump, John A.
Breiman, Robert F.
Adu-Sarkodie, Yaw
Owusu-Dabo, Ellis
Rakotozandrindrainy, Raphael
Soura, Abdramane Bassiahi
Aseffa, Abraham
Gasmelseed, Nagla
Keddy, Karen H.
May, Juergen
Sow, Amy Gassama
Aaby, Peter
Biggs, Holly M.
Hertz, Julian T.
Montgomery, Joel M.
Cosmas, Leonard
Olack, Beatrice
Fields, Barry
Sarpong, Nimako
Razafindrabe, Tsiriniaina Jean Luco
Raminosoa, Tiana Mirana
Kabore, Leon Parfait
Sampo, Emmanuel
Teferi, Mekonnen
Yeshitela, Biruk
El Tayeb, Muna Ahmed
Sooka, Arvinda
Meyer, Christian G.
Krumkamp, Ralf
Dekker, Denise Myriam
Jaeger, Anna
Poppert, Sven
Tall, Adama
Niang, Aissatou
Bjerregaard-Andersen, Morten
Lofberg, Sandra Valborg
Seo, Hye Jin
Jeon, Hyon Jin
Deerin, Jessica Fung
Park, Jinkyung
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