Bovine milk lactoferrin modulates the proliferative lymphocyte response to phytohemagglutinin

被引：0
|
作者：
Noritsugu Yabe
Yasuharu Itagaki
Morimasa Tanimoto
Hisao Matsui
机构：
[1] Dokkyo University School of Medicine,Department of Hygiene
[2] Snow Brand Milk Products Co.,Sapporo Research Laboratory
[3] Ltd.,undefined
来源：
Biotechnology Letters | 1999年 / 21卷
关键词：
lactoferrin; lymphocytes; modulation; phytohemagglutinin; proliferation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Bovine milk lactoferrin (2 to 20 μg ml−1) changed enhancement of [3H]thymidine incorporation by phytohemagglutinin-stimulated rat spleen lymphocytes into suppression as their lactoferrin-withdrawal incorporation increased to greater than 10 000 cpm culture−1 under the present isotope-labeling conditions. The enhancement disappeared by 15-min delayed addition of lactoferrin after addition of lectin. There was no lactoferrin effect when the cells were stimulated with 12-O-tetradecanoylphorbol-13-acetate plus ionomycin. Thus, lactoferrin has a certain extracellular effect on lymphocyte proliferation in response to the lectin.
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页码：1083 / 1089
页数：6
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