Polymorphisms in the prostate-specific antigen gene promoter do not predict serum prostate-specific antigen levels in African-American men

被引：0
|
作者：
J L Beebe-Dimmer
L A Lange
J E Cain
R C Lewis
A M Ray
A V Sarma
E M Lange
K A Cooney
机构：
[1] University of Michigan Medical School,Department of Urology
[2] University of Michigan School of Public Health,Department of Epidemiology
[3] Department of Genetics,Department of Internal Medicine
[4] University of North Carolina,Department of Biostatistics
[5] University of Michigan Medical School,undefined
[6] University of North Carolina,undefined
来源：
Prostate Cancer and Prostatic Diseases | 2006年 / 9卷
关键词：
prostate-specific antigen; single-nucleotide polymorphism; PSA gene;
D O I：
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学科分类号：
摘要：
A major problem with the use of serum prostate-specific antigen (PSA) in predicting prostate cancer risk is the considerable variability of such measurements. Cramer et al. identified a set of single-nucleotide polymorphisms (SNPs) in the upstream regulatory region of the PSA gene that were each associated with increased promoter activity and serum PSA, further suggesting that genotyping these SNPs could be useful in improving the predictive value of PSA screening. In order to replicate this finding, DNA samples from 475 African-American men were genotyped for the same SNPs and no association was observed with either serum PSA level or prostate cancer diagnosis.
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页码：50 / 55
页数：5
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