A New Antibacterial Chlorinated Amino Acid Derivative from the Sponge-Derived Fungus Aspergillus sp. LS53

被引：0
|
作者：
Lu Zhang
Panpan Qiu
Lijian Ding
Qiang Li
Jingjing Song
Zhiwen Han
Shan He
机构：
[1] Ningbo University,Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center
来源：
Chemistry of Natural Compounds | 2020年 / 56卷
关键词：
sp.; 3-chloro-4-hydroxyphenyl unit; sponge-derived fungi; antibacterial activity;
D O I：
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学科分类号：
摘要：
A new chlorinated amino acid derivative with a rare 3-chloro-4-hydroxyphenyl unit named aspergamide A (1), along with three known compounds, xylarinol A (2), nectriapyrone (3), and asperisocoumarin A (4), were isolated from the sponge-derived fungus Aspergillus sp. LS53. Their structures were determined by combining detailed spectroscopic analysis and literature data. Compounds 1, 3, and 4 showed weak Vibrio harveyi inhibition with MIC values ranging from 16 to 64 μg/mL, whereas 2 was found to be inactive.
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页码：109 / 111
页数：2
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