Steroid Hormones and Uterine Vascular Adaptation to Pregnancy

被引:0
|
作者
Katherine Chang
Lubo Zhang
机构
[1] Loma Linda University,Center for Perinatal Biology, Department of Physiology and Pharmacology
[2] School of Medicine,undefined
来源
Reproductive Sciences | 2008年 / 15卷
关键词
Uterine artery; pregnancy; steroid hormone;
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摘要
Pregnancy is a physiological state that involves a significant decrease in uterine vascular tone and an increase in uterine blood flow, which is mediated in part by steroid hormones, including estrogen, progesterone, and cortisol. Previous studies have demonstrated the involvement of these hormones in the regulation of uterine artery contractility through signaling pathways specific to the endothelium and the vascular smooth muscle. Alterations in endothelial nitric oxide synthase expression and activity, nitric oxide production, and expression of enzymes involved in PGI2 production contribute to the uterine artery endothelium—specific responses. Steroid hormones also have an effect on calcium-activated potassium channel activity, PKC signaling pathway and myogenic tone, and alterations in pharmacomechanical coupling in the uterine artery smooth muscle. This review addresses current understanding of the molecular mechanisms by which steroid hormones including estrogen, progesterone, and cortisol modulate uterine artery contractility to alter uterine blood flow during pregnancy with an emphasis on the pregnant ewe model.
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页码:336 / 348
页数:12
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