The downregulation of Mcl-1 via USP9X inhibition sensitizes solid tumors to Bcl-xl inhibition

被引:0
|
作者
Chander Peddaboina
Daniel Jupiter
Steven Fletcher
Jeremy L Yap
Arun Rai
Richard P Tobin
Weihua Jiang
Philip Rascoe
M Karen Newell Rogers
W Roy Smythe
Xiaobo Cao
机构
[1] The Texas A&M University System,Department of Surgery, Scott & White Memorial Hospital and Clinic
[2] Health Science Center,Department of Pharmaceutical Sciences
[3] College of Medicine,undefined
[4] University of Maryland School of Pharmacy,undefined
[5] Boston University School of Medicine,undefined
来源
BMC Cancer | / 12卷
关键词
Mcl-1; Bcl-xL; USP9X; Ubiquitination; Cancer;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [1] The downregulation of Mcl-1 via USP9X inhibition sensitizes solid tumors to Bcl-xl inhibition
    Peddaboina, Chander
    Jupiter, Daniel
    Fletcher, Steven
    Yap, Jeremy L.
    Rai, Arun
    Tobin, Richard P.
    Jiang, Weihua
    Rascoe, Philip
    Rogers, M. Karen Newell
    Smythe, W. Roy
    Cao, Xiaobo
    BMC CANCER, 2012, 12
  • [2] Photodynamic Therapy Combined with Bcl-2/Bcl-xL Inhibition Increases the Noxa/Mcl-1 Ratio Independent of Usp9X and Synergistically Enhances Apoptosis in Glioblastoma
    Golla, Carolin
    Bilal, Mayas
    Dwucet, Annika
    Bader, Nicolas
    Anthonymuthu, Jenson
    Heiland, Tim
    Pruss, Maximilian
    Westhoff, Mike-Andrew
    Siegelin, Markus David
    Capanni, Felix
    Wirtz, Christian Rainer
    Kast, Richard Eric
    Halatsch, Marc-Eric
    Karpel-Massler, Georg
    CANCERS, 2021, 13 (16)
  • [3] CONCOMITANT INHIBITION OF RAC1 AND Bcl-2/Bcl-xL INTERFERES WITH THE Mcl-1/Usp9X AXIS AND YIELDS SYNERGISTIC ANTI-GLIOMA ACTIVITY
    Hlavac, Michal
    Dwucet, Annika
    Westhoff, Mike-Andrew
    Kast, Richard Eric
    Engelke, Jens
    Siegelin, Markus
    Wirtz, Christian Rainer
    Halatsch, Marc-Eric
    Karpel-Massler, Georg
    NEURO-ONCOLOGY, 2018, 20 : 96 - 97
  • [4] Combined inhibition of RAC1 and Bcl-2/Bcl-xL synergistically induces glioblastoma cell death through down-regulation of the Usp9X/Mcl-1 axis
    Hlavac, Michal
    Dwucet, Annika
    Kast, Richard Eric
    Engelke, Jens
    Westhoff, Mike-Andrew
    Siegelin, Markus D.
    Debatin, Klaus-Michael
    Wirtz, Christian Rainer
    Halatsch, Marc-Eric
    Karpel-Massler, Georg
    CELLULAR ONCOLOGY, 2019, 42 (03) : 287 - 301
  • [5] Combined inhibition of RAC1 and Bcl-2/Bcl-xL synergistically induces glioblastoma cell death through down-regulation of the Usp9X/Mcl-1 axis
    Michal Hlavac
    Annika Dwucet
    Richard Eric Kast
    Jens Engelke
    Mike-Andrew Westhoff
    Markus D. Siegelin
    Klaus-Michael Debatin
    Christian Rainer Wirtz
    Marc-Eric Halatsch
    Georg Karpel-Massler
    Cellular Oncology, 2019, 42 : 287 - 301
  • [6] mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1
    Coffee, Erin M.
    Faber, Anthony C.
    Costa, Carlotta
    Dastur, Anahita
    Ebi, Hiromichi
    Hata, Aaron N.
    Yeo, Alan T.
    Elena, J.
    Song, Youngchul
    Tam, Ah Ting
    Boisvert, Jessica L.
    Milano, Randy J.
    Roper, Jatin
    Kodack, David P.
    Jain, Rakesh K.
    Corcoran, Ryan B.
    Rivera, Miguel N.
    Ramaswamy, Sridhar
    Hung, Kenneth E.
    Benes, Cyril H.
    Engelman, Jeffrey A.
    MOLECULAR CANCER THERAPEUTICS, 2013, 12 (11)
  • [7] mTOR Inhibition Specifically Sensitizes Colorectal Cancers with KRAS or BRAF Mutations to BCL-2/BCL-XL Inhibition by Suppressing MCL-1
    Faber, Anthony C.
    Coffee, Erin M.
    Costa, Carlotta
    Dastur, Anahita
    Ebi, Hiromichi
    Hata, Aaron N.
    Yeo, Alan T.
    Edelman, Elena J.
    Song, Youngchul
    Tam, Ah Ting
    Boisvert, Jessica L.
    Milano, Randy J.
    Roper, Jatin
    Kodack, David P.
    Jain, Rakesh K.
    Corcoran, Ryan B.
    Rivera, Miguel N.
    Ramaswamy, Sridhar
    Hung, Kenneth E.
    Benes, Cyril H.
    Engelman, Jeffrey A.
    CANCER DISCOVERY, 2014, 4 (01) : 42 - 52
  • [8] SYNERGISTIC AND ON-TARGET ACTIVITY OF DUAL BCL-2/BCL-XL INHIBITION TOGETHER WITH INHIBITION OF MCL-1
    Wichert, Maren
    Niedermayer, Alexandra
    Enzenmueller, Stefanie
    Debatin, Klaus-Michael
    Meyer, Lüder
    Seyfried, Felix
    PEDIATRIC BLOOD & CANCER, 2022, 69
  • [9] MCL-1 and BCL-XL: blood brothers
    Erlacher, Miriam
    Labi, Verena
    BLOOD, 2021, 137 (14) : 1850 - 1851
  • [10] Inhibition of Antiapoptotic BCL-XL, BCL-2, and MCL-1 Proteins by Small Molecule Mimetics
    Dalafave, D. S.
    Prisco, G.
    CANCER INFORMATICS, 2010, 9 : 169 - 177