An essential role for XBP-1 in host protection against immune activation in C. elegans

被引：0
|
作者：
Claire E. Richardson
Tristan Kooistra
Dennis H. Kim
机构：
[1] Massachusetts Institute of Technology,Department of Biology
[2] Cambridge,undefined
[3] Massachusetts 02139,undefined
[4] USA,undefined
来源：
Nature | 2010年 / 463卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The unfolded protein response (UPR), a signalling pathway activated by the accumulation of unfolded proteins in the endoplasmic reticulum, is known to contribute to the defence against infectious agents and toxins. Here it is shown that activation of innate immunity in Caenorhabditis elegans induces the UPR mediated by X-box binding protein 1 (XBP-1). This points to an ancient, conserved role for the XBP-1-dependent UPR in protecting cells against the endoplasmic reticulum stress generated from an immune response.
引用
收藏
页码：1092 / 1095
页数：3
相关论文
共 50 条
  • [1] An essential role for XBP-1 in host protection against immune activation in C. elegans
    Richardson, Claire E.
    Kooistra, Tristan
    Kim, Dennis H.
    NATURE, 2010, 463 (7284) : 1092 - U114
  • [2] Neuronal XBP-1 Activates Intestinal Lysosomes to Improve Proteostasis in C. elegans
    Imanikia, Soudabeh
    Ozbey, Nesem P.
    Krueger, Christel
    Casanueva, M. Olivia
    Taylor, Rebecca C.
    CURRENT BIOLOGY, 2019, 29 (14) : 2322 - +
  • [3] XBP-1 is Essential Host Factor for Leishmania Amazonensis pathogenicity.
    Dais Teixeira, K.
    Aktas, B. H.
    Lopes, U. G.
    MOLECULAR BIOLOGY OF THE CELL, 2015, 26
  • [4] An essential role in liver development for transcription factor XBP-1
    Reimold, AM
    Etkin, A
    Clauss, I
    Perkins, A
    Friend, DS
    Zhang, J
    Horton, HF
    Scott, A
    Orkin, SH
    Byrne, MC
    Grusby, MJ
    Glimcher, LH
    GENES & DEVELOPMENT, 2000, 14 (02) : 152 - 157
  • [5] Role of the Nervous System in the Control of Proteostasis Innate Immune Activation: Insights from C. elegans
    Aballay, Alejandro
    PLOS PATHOGENS, 2013, 9 (08):
  • [6] IRE-1/XBP-1 pathway of the unfolded protein response is required for properly localizing neuronal UNC-6/Netrin for axon guidance in C. elegans
    Asakura, Taro
    Ogura, Ken-ichi
    Goshima, Yoshio
    GENES TO CELLS, 2015, 20 (03) : 153 - 159
  • [7] Protection against heat stress injury of deuterohemin peptide in C. elegans
    Wang, L.
    JOURNAL OF PEPTIDE SCIENCE, 2010, 16 : 129 - 130
  • [8] TNF-dependent regulation and activation of innate immune cells are essential for host protection against cerebral tuberculosis
    Ngiambudulu M. Francisco
    Nai-Jen Hsu
    Roanne Keeton
    Philippa Randall
    Boipelo Sebesho
    Nasiema Allie
    Dhirendra Govender
    Valerie Quesniaux
    Bernhard Ryffel
    Lauriston Kellaway
    Muazzam Jacobs
    Journal of Neuroinflammation, 12
  • [9] TNF-dependent regulation and activation of innate immune cells are essential for host protection against cerebral tuberculosis
    Francisco, Ngiambudulu M.
    Hsu, Nai-Jen
    Keeton, Roanne
    Randall, Philippa
    Sebesho, Boipelo
    Allie, Nasiema
    Govender, Dhirendra
    Quesniaux, Valerie
    Ryffel, Bernhard
    Kellaway, Lauriston
    Jacobs, Muazzam
    JOURNAL OF NEUROINFLAMMATION, 2015, 12
  • [10] C. elegans host defense pathways protect against microbiota cryptic virulence
    Gonzalez, Xavier
    Wollenberg, Amanda
    Irazoqui, Javier
    JOURNAL OF IMMUNOLOGY, 2022, 208 (01):
12345