The risk of gastrointestinal carcinoma in familial juvenile polyposis

被引:0
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作者
James R. Howe
Frank A. Mitros
Robert W. Summers
机构
[1] University of Iowa College of Medicine,the Department of Pathology
[2] University of Iowa College of Medicine,the Department of Medicine
[3] University of Iowa College of Medicine,Dept. of Surgery
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关键词
Juvenile polyposis; Gastrointestinal carcinoma; Colorectal cancer;
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摘要
Background: Familial juvenile polyposis (JP) is an autosomal dominant condition in which affected individuals develop upper or lower gastrointestinal (GI) juvenile polyps, or both, and have a predisposition to cancer of the gastrointestinal tract. The risk of GI cancer has not been well defined because of the small number of these families and the lack of follow-up. The objective of this study was to determine the prevalence and age at diagnosis of GI polyposis and cancer in a large JP kindred.
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页码:751 / 756
页数:5
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