In vivo actions of the selective 5-HT1A receptor agonist BAY x 3702 on serotonergic cell firing and release

被引：0
|
作者：
Josep M. Casanovas
Olivier Berton
Pau Celada
Francesc Artigas
机构：
[1] Department of Neurochemistry,
[2] Institut d'Investigacions Biomèdiques de Barcelona (CSIC),undefined
[3] IDIBAPS,undefined
[4] 6th floor,undefined
[5] Rosselló,undefined
[6] 161,undefined
[7] E-08036 Barcelona,undefined
[8] Spain,undefined
[9] Present address: UCB Pharma,undefined
[10] Preclinical CNS Research Group,undefined
[11] Braine-l'Alleud,undefined
[12] Belgium,undefined
来源：
Naunyn-Schmiedeberg's Archives of Pharmacology | 2000年 / 362卷
关键词：
5-HT1A receptors Dorsal raphe nucleus Hippocampus Median raphe nucleus Microdialysis Prefrontal cortex Single unit recordings;
D O I：
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学科分类号：
摘要：
We investigated the effects of the novel 5-HT1A receptor agonist BAY x 3702 on the serotonergic function in rat brain using single unit recordings in the dorsal raphe nucleus (DR) of anesthetized rats and in vivo microdialysis in freely moving rats. The administration of BAY x 3702 (0.25–4 µg/kg i.v.) suppressed the firing activity of 5-HT neurones. This effect was antagonized by a low dose of the selective 5-HT1A receptor antagonist WAY 100635 (5 µg/kg i.v.).
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页码：248 / 254
页数：6
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