Advances in genome-wide association studies of complex traits in rice

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作者
Qin Wang
Jiali Tang
Bin Han
Xuehui Huang
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[1] Shanghai Normal University,Shanghai Key Laboratory of Plant Molecular Sciences, College of Life Sciences
[2] Chinese Academy of Sciences,National Center for Gene Research, CAS Center for Excellence of Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences
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摘要
Genome-wide association studies (GWAS), genetic surveys of the whole genome to detect variants associated with a trait in natural populations, are a powerful approach for dissecting complex traits. This genetic mapping approach has been applied in rice over the last 10 years. During the last decade, GWAS was used to identify the loci underlying tens of rice traits, and several important genes were detected in GWAS and further confirmed in follow-up functional experiments. In this review, we present an overview of the whole process in a typical GWAS, including population design, genotyping, phenotyping and analysis methods. Recent advances in rice GWAS are also provided, including several examples of the functional characterization of candidate genes. The possible breakthroughs of rice GWAS in the next decade are discussed with regard to their application in breeding, the consideration of epistatic interactions and in-depth functional annotations of DNA elements and genetic variants throughout the rice genome.
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页码:1415 / 1425
页数:10
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