Brain contents of substance P, diazepam-binding inhibitor, and neuropeptide Y in high- and low-anxiety inbred rats during stress

被引：0

作者：

S. K. Sudakov

N. N. Terebilina

O. F. Medvedeva

I. V. Rusakova

S. R. Goldberg

机构：

[1] Russian Ministry of Health,Laboratory of Attraction Neurobiology and Laboratory of Biochemistry, Institute of Drug Abuse

[2] National Institute of Drug Abuse,Department of Preclinical Pharmacology

[3] American National Institute of Health,undefined

来源：

Bulletin of Experimental Biology and Medicine | 1999年 / 128卷

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摘要：

The content of substance P in the hippocampus, hypothalamus, and midbrain of WAG/G rats surpassed these in Fischer-344 rats. After a 15-min stay in a shuttle box, the level of substance P in the hypothalamus and especially in the hippocampus decreased only in WAG/G rats. The content of diazepam-binding inhibitor in the hippocampus and midbrain of WAG/G rats was higher than in Ficher-344 rats. Stress increased the content of diazepam-binding inhibitor only in Fischer-344 rats. Midbrain content of neuropeptide Y in intact and stressed WAG/G rats was significantly lower than in Fischer-344 rats. There were no interstrain differences in the initial hypothalamic levels of neuropeptide Y between WAG/G and Fischer-344 rats. However, 15-min stress in the shuttle box increased hypothalamic content of neuropeptide Y only in Fischer-344 rats. Thus, high-anxiety rats are characterized by a low density of benzodiazepine receptors, decreased levels of substance P and diazepam-binding inhibitor, and high brain content of neuropeptide Y.

引用

页码：879 / 881

页数：2

共 8 条

[1] Brain contents of substance P, diazepam-binding inhibitor, and neuropeptide Y in high- and low-anxiety inbred rats during stress
Sudakov, SK
Terebilina, NN
Medvedeva, OF
Rusakova, IV
Goldberg, SR
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 1999, 128 (09) : 879 - 881
[2] Differences in genetic predisposition to high anxiety in two inbred rat strains: role of substance P, diazepam binding inhibitor fragment and neuropeptide Y
S.K. Sudakov
O.F. Medvedeva
I.V. Rusakova
N.N. Terebilina
S.R. Goldberg
Psychopharmacology, 2001, 154 : 327 - 335
[3] Differences in genetic predisposition to high anxiety in two inbred rat strains: role of substance P, diazepam binding inhibitor fragment and neuropeptide Y
Sudakov, SK
Medvedeva, OF
Rusakova, IV
Terebilina, NN
Goldberg, SR
PSYCHOPHARMACOLOGY, 2001, 154 (04) : 327 - 335
[4] Behavioral effects and CRF expression in brain structures of high- and low-anxiety rats after chronic restraint stress
Wislowska-Stanek, Aleksandra
Lehner, Malgorzata
Skorzewska, Anna
Krzascik, Pawel
Plaznik, Adam
BEHAVIOURAL BRAIN RESEARCH, 2016, 310 : 26 - 35
[5] Behavioral, Physiological, and Neuroendocrine Stress Responses and Differential Sensitivity to Diazepam in Two Wistar Rat Lines Selectively Bred for High- and Low-Anxiety–Related Behavior
Gudrun Liebsch
Astrid CE Linthorst
Inga D Neumann
Johannes MHM Reul
Florian Holsboer
Rainer Landgraf
Neuropsychopharmacology, 1998, 19 : 381 - 396
[6] Extracellular amino acid levels in the paraventricular nucleus and the central amygdala in high- and low-anxiety dams rats during maternal aggression: Regulation by oxytocin
Bosch, Oliver J.
Sartori, Simone B.
Singewald, Nicolas
Neumann, Inga D.
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS, 2007, 10 (03): : 261 - 270
[7] Genetic predisposition to high anxiety in rats may be determined by a low level of substance P in the brain
Sudakov, SK
Terebilina, NN
Medvedeva, OF
Rusakova, IV
Goldberg, SR
BRAIN RESEARCH, 1999, 848 (1-2) : A34 - A34
[8] Contribution of amygdala neurons containing peptides and calcium-binding proteins to fear-potentiated startle and exploration-related anxiety in inbred Roman high- and low-avoidance rats
Yilmazer-Hanke, DM
Faber-Zuschratter, H
Linke, R
Schwegler, H
EUROPEAN JOURNAL OF NEUROSCIENCE, 2002, 15 (07) : 1206 - 1218

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