RETRACTED ARTICLE: HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs

被引：0

作者：

H Zhang

C C L Wong

H Wei

D M Gilkes

P Korangath

P Chaturvedi

L Schito

J Chen

B Krishnamachary

P T Winnard

V Raman

L Zhen

W A Mitzner

S Sukumar

G L Semenza

机构：

[1] Vascular Program,Department of Oncology

[2] Institute for Cell Engineering,Department of Radiology

[3] The Johns Hopkins University School of Medicine,Division of Physiology

[4] The Johns Hopkins University School of Medicine,Departments of Pediatrics

[5] McKusick-Nathans Institute of Genetic Medicine,undefined

[6] The Johns Hopkins University School of Medicine,undefined

[7] The Johns Hopkins University School of Medicine,undefined

[8] School of Life Science,undefined

[9] The University of Science and Technology of China,undefined

[10] University of Rome ‘La Sapienza’,undefined

[11] The Johns Hopkins University School of Public Health,undefined

[12] Medicine,undefined

[13] Radiation Oncology,undefined

[14] and Biological Chemistry,undefined

[15] The Johns Hopkins University School of Medicine,undefined

来源：

Oncogene | 2012年 / 31卷

关键词：

breast cancer; metastasis; hypoxia;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Most cases of breast cancer (BrCa) mortality are due to vascular metastasis. BrCa cells must intravasate through endothelial cells (ECs) to enter a blood vessel in the primary tumor and then adhere to ECs and extravasate at the metastatic site. In this study we demonstrate that inhibition of hypoxia-inducible factor (HIF) activity in BrCa cells by RNA interference or digoxin treatment inhibits primary tumor growth and also inhibits the metastasis of BrCa cells to the lungs by blocking the expression of angiopoietin-like 4 (ANGPTL4) and L1 cell adhesion molecule (L1CAM). ANGPTL4 is a secreted factor that inhibits EC–EC interaction, whereas L1CAM increases the adherence of BrCa cells to ECs. Interference with HIF, ANGPTL4 or L1CAM expression inhibits vascular metastasis of BrCa cells to the lungs.

引用

页码：1757 / 1770

页数：13

共 20 条

[1] Correction: HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs
H. Zhang
C. C. L. Wong
H. Wei
D. M. Gilkes
P. Korangath
P. Chaturvedi
L. Schito
J. Chen
B. Krishnamachary
P. T. Winnard
V. Raman
L. Zhen
W. A. Mitzner
S. Sukumar
G. L. Semenza
Oncogene, 2021, 40 : 1552 - 1553
[2] Retraction Note: HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs
H. Zhang
C. C. L. Wong
H. Wei
D. M. Gilkes
P. Korangath
P. Chaturvedi
L. Schito
J. Chen
B. Krishnamachary
P. T. Winnard
V. Raman
L. Zhen
W. A. Mitzner
S. Sukumar
G. L. Semenza
Oncogene, 2023, 42 : 2234 - 2234
[3] RETRACTED: HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs (Retracted article. See MAY, 2023)
Zhang, H.
Wong, C. C. L.
Wei, H.
Gilkes, D. M.
Korangath, P.
Chaturvedi, P.
Schito, L.
Chen, J.
Krishnamachary, B.
Winnard, P. T., Jr.
Raman, V.
Zhen, L.
Mitzner, W. A.
Sukumar, S.
Semenza, G. L.
ONCOGENE, 2012, 31 (14) : 1757 - 1770
[4] HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs (vol 31, pg 1757, 2012)
Zhang, H.
Wong, C. C. L.
Wei, H.
Gilkes, D. M.
Korangath, P.
Chaturvedi, P.
Schito, L.
Chen, J.
Krishnamachary, B.
Winnard, P. T., Jr.
Raman, V.
Zhen, L.
Mitzner, W. A.
Sukumar, S.
Semenza, G. L.
ONCOGENE, 2021, 40 (08) : 1552 - 1553
[5] RETRACTION: HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs (vol 31, pg 1757, 2012) (Retraction of Vol 31, Pg 1757, 2012)
Zhang, H.
Wong, C. C. L.
Wei, H.
Gilkes, D. M.
Korangath, P.
Chaturvedi, P.
Schito, L.
Chen, J.
Krishnamachary, B.
Winnard, P. T.
Raman, V.
Zhen, L.
Mitzner, W. A.
Sukumar, S.
Semenza, G. L.
ONCOGENE, 2023, 42 (28) : 2234 - 2234
[6] Hypoxic retinal Muller cells promote vascular permeability by HIF-1-dependent up-regulation of angiopoietin-like 4
Xin, Xiaoban
Rodrigues, Murilo
Umapathi, Mahaa
Kashiwabuchi, Fabiana
Ma, Tao
Babapoor-Farrokhran, Savalan
Wang, Shuang
Hu, Jiadi
Bhutto, Imran
Welsbie, Derek S.
Duh, Elia J.
Handa, James T.
Eberhart, Charles G.
Lutty, Gerard
Semenza, Gregg L.
Montaner, Silvia
Sodhi, Akrit
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (36) : E3425 - E3434
[7] β-arrestin1 mediates metastatic growth of breast cancer cells by facilitating HIF-1-dependent VEGF expression
Shenoy, S. K.
Han, S.
Zhao, Y. L.
Hara, M. R.
Oliver, T.
Cao, Y.
Dewhirst, M. W.
ONCOGENE, 2012, 31 (03) : 282 - 292
[8] β-arrestin1 mediates metastatic growth of breast cancer cells by facilitating HIF-1-dependent VEGF expression
S K Shenoy
S Han
Y L Zhao
M R Hara
T Oliver
Y Cao
M W Dewhirst
Oncogene, 2012, 31 : 282 - 292
[9] RETRACTED: Rapamycin Inhibits Proliferation of Hemangioma Endothelial Cells by Reducing HIF-1-Dependent Expression of VEGF (Retracted Article)
Medici, Damian
Olsen, Bjorn R.
PLOS ONE, 2012, 7 (08):
[10] Alpha1-antitrypsin combined fatty acids induced angiopoietin-like protein 4, expression in breast cancer: A pilot study
Preethika, A.
Kumai, N. Suchetha
Sandeep, Ail
Shetty, Jayarama
CHEMISTRY AND PHYSICS OF LIPIDS, 2022, 243

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