Effect of Sub-Acute Toxicity of Bifenthrin on Antioxidant status and Hematology After its Oral Exposure in Goats

The current study was undertaken to investigate the potential oxidative stress and hematological alterations induced by sub-acute oral exposure of bifenthrin in goats, after its repeated oral administration, at the dose rate of 5 mg/kg body weight daily for 28 days. The oxidative stress parameters such as malondialdehyde, blood glutathione, superoxide dismutase, catalase, glutathione peroxidase and glutathione s-transferase were studied on days 0, 3, 7, 14, 21 and 28 of bifenthrin exposure and days 7 and 14 of post-exposure period. To explore the relationship of oxidative stress with the alterations in hematological parameters like hemoglobin, packed cell volume and total erythrocyte count were also studied, simultaneously. The bifenthrin-exposed animals showed a significant increase in malondialdehyde level, whereas, the significant decrease in the levels of antioxidant parameters was noticed. A significant decrease in hemoglobin, packed cell volume and total erythrocyte count was reported, indicating a close relationship of oxidative stress and hematological alterations. After bifenthrin withdrawal, there was an improvement in the condition, as indicated by reversal in both oxidative stress and hematological parameters to the normal range.