Molecular Mechanisms of Changes in TNF-α Production by Blood Mononuclears in Chronic Viral Hepatitis C

被引：0
|
作者：
N. V. Ryazantseva
I. O. Naslednikova
A. P. Zima
V. V. Novitskii
N. V. Tokareva
E. V. Beloborodova
V. V. Belokon’
M. A. Antoshina
Yu. V. Minochenko
Yu. V. Tomson
E. A. Piguzova
机构：
[1] Siberian State Medical University,Department of Pathophysiology, Department of Fundamentals of Clinical Medicine
[2] Ministry of Health of Russian Federation,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2005年 / 139卷
关键词：
chronic viral hepatitis; hepatitis C virus; TNF-α; TNF-α soluble receptor;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Chronic viral hepatitis C is associated with decreased production of TNF-α by the peripheral blood mononuclear leukocytes irrespective of virus genotype and degree of the morphological activity of the process in the liver. This process positively correlates with the increase in the content of TNF-α soluble receptor (molecular weight 55 kDa), which can play a role in the mechanisms of immunopathogenesis of long persistence of hepatitis C virus in the body.
引用
收藏
页码：223 / 226
页数：3
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