Fast Dissolution Dynamic Nuclear Polarization NMR of 13C-Enriched 89Y-DOTA Complex: Experimental and Theoretical Considerations

被引：0
|
作者：
Lloyd Lumata
Matthew Merritt
Craig Malloy
A. Dean Sherry
Zoltan Kovacs
机构：
[1] Advanced Imaging Research Center,Department of Chemistry
[2] University of Texas Southwestern Medical Center,undefined
[3] University of Texas at Dallas,undefined
来源：
Applied Magnetic Resonance | 2012年 / 43卷
关键词：
Nuclear Magnetic Resonance; Dynamic Nuclear Polarization; Nuclear Magnetic Resonance Signal; Nuclear Magnetic Resonance Tube; Nuclear Larmor Frequency;
D O I：
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中图分类号：
学科分类号：
摘要：
The yttrium complex of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra(1′-13C-acetic acid) [13C]DOTA was synthesized. Fast dissolution dynamic nuclear polarization (DNP) nuclear magnetic resonance (NMR) studies revealed that the 89Y, 13C, and 15N nuclei present in the complex could be co-polarized at the same optimum microwave irradiation frequency. The liquid-state spin–lattice relaxation time T1 of these nuclei were found to be reasonably long to preserve some or most of the DNP-enhanced polarization after dissolution. The hyperpolarized 13C and 89Y NMR signals were optimized in different glassing mixtures. The overall results are discussed in light of the thermal mixing model of DNP.
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页码：69 / 79
页数：10
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