Calcium flickers steer cell migration

被引：0
|
作者：
Chaoliang Wei
Xianhua Wang
Min Chen
Kunfu Ouyang
Long-Sheng Song
Heping Cheng
机构：
[1] Institute of Molecular Medicine,Department of Internal Medicine, Division of Cardiovascular Medicine
[2] State Key Laboratory of Biomembrane and Membrane Biotechnology,undefined
[3] Peking University,undefined
[4] University of Iowa Carver College of Medicine,undefined
[5] Iowa City,undefined
[6] Iowa 52242,undefined
[7] USA,undefined
来源：
Nature | 2009年 / 457卷
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摘要：
Directional cell movement depends on an intracellular calcium gradient. In a study of migrating fibroblasts, Chaoliang Wei et al. have identified calcium flickers — high-calcium microdomains — as part of the mechanism that steers cells to their targets. The flickers are most active at the leading edge of migrating cells. In the presence of a chemotactic gradient, an asymmetric gradient of calcium flicker activity develops which promotes turning of cells towards the direction of the chemoattractant.
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页码：901 / 905
页数：4
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