Synthesis and Inhibitory Properties of Imines Containing Monoterpenoid and Adamantane Fragments Against DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1 (Tdp1)

被引：0
|
作者：
A. L. Zakharenko
E. S. Mozhaitsev
E. V. Suslov
D. V. Korchagina
K. P. Volcho
N. F. Salakhutdinov
O. I. Lavrik
机构：
[1] Russian Academy of Sciences,Institute of Chemical Biology and Fundamental Medicine, Siberian Branch
[2] Russian Academy of Sciences,N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch
[3] Novosibirsk State University,undefined
来源：
Chemistry of Natural Compounds | 2018年 / 54卷
关键词：
adamantane; monoterpene; tyrosyl-DNA phosphodiesterase 1; DNA repair inhibitor; Schiff base;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Six imines including four new ones were synthesized via the reaction of monoterpenoid aldehydes with aminoadamantanes. The inhibitory activities of the synthesized compounds against purified human recombinant DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 (Tdp1) fell in the range IC50 = 5.5–7.1 μM.
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页码：672 / 676
页数：4
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