Alcoholic Cardiomyopathy: Translation Model

被引：0
|
作者：
S. A. Kryzhanovskii
L. G. Kolik
I. B. Tsorin
V. N. Stolyaruk
M. B. Vititnova
E. O. Ionova
A. V. Sorokina
A. D. Durnev
机构：
[1] V. V. Zakusov Research Institute of Pharmacology,
来源：
Bulletin of Experimental Biology and Medicine | 2017年 / 163卷
关键词：
translation model; alcoholic cardiomyopathy; echocardiography; morphology; sudden death;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We developed a translation model of alcoholic cardiomyopathy in rats. By the end of forced alcoholization (the rats received 10% ethanol solution as the only source of fluid for 24 weeks; mean daily ethanol consumption was 5.0-6.5 g/kg), the rats developed dilated heart failure. Echocardiography and morphometric study of the myocardium revealed a decrease in inotropic function of the heart and dilatation of the right and left ventricles. Fatty degeneration of the myocardium (pathognomonic sign of alcoholic cardiomyopathy) and decrease in electrical stability of cardiomyocytes reliably reproduce the clinical pattern of alcoholic cardiomyopathy.
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页码：627 / 631
页数：4
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