Retrospective study of the immunogenicity and safety of the CoronaVac SARS-CoV-2 vaccine in people with underlying medical conditions

被引：0

作者：

Chunmei Li

Hanfang Bi

Zhenwang Fu

Ao Li

Na Wan

Jun Hu

Fan Yang

Tai-Cheng Zhou

Yupeng Liang

Wei Su

Tianpei Shi

Mei Yang

Rong Wang

Wanting Qin

Xuanjing Yu

Hong-Yi Zheng

Zumi Zhou

Yong-Tang Zheng

Jia Wei

Gang Zeng

Zijie Zhang

机构：

[1] Yunnan University,State Key Laboratory for Conservation and Utilization of Bio

[2] Hainan Center for Disease Control and Prevention,resources and School of Life Sciences

[3] The Affiliated Hospital of Yunnan University,Outpatient department

[4] The Affiliated Hospital of Yunnan University,Central Lab and Liver Disease Research Center

[5] Sinovac Biotech Co. Ltd.,State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology

[6] Chinese Academy of Sciences,College of Life Science

[7] University of Chinese Academy of Sciences,Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences, KIZ

[8] Chinese Academy of Sciences,CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology

[9] The Affiliated Hospital of Yunnan University,Central Lab and Liver Disease Research Center

[10] Peking University First Hospital,Renal Division, Department of Medicine

[11] Renal Pathology Center,Guangdong Provincial Key Laboratory of Tropical Disease Research, Department of Biostatistics, School of Public Health

[12] Institute of Nephrology,School of Public Health

[13] Peking University,Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, Institute of Biomedical Engineering

[14] Key Laboratory of Renal Disease,Yunnan Key Laboratory of Stomatology

[15] Ministry of Health of China,Department of Preventive Medicine

[16] Key Laboratory of CKD Prevention and Treatment,undefined

[17] Ministry of Education of China; Research Units of Diagnosis and Treatment of Immune-Mediated Kidney Diseases,undefined

[18] Chinese Academy of Medical Sciences,undefined

[19] Southern Medical University,undefined

[20] Kunming Medical University,undefined

[21] Kunming Medical University,undefined

[22] Kunming Medical University,undefined

[23] The Affiliated Hospital of Yunnan University,undefined

[24] Yunnan University,undefined

来源：

Communications Medicine | / 2卷

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摘要：

People living with chronic diseases, particularly those over the age of 60, are more likely to have severe symptoms and die following SARS-CoV-2 infection. However, many have not been vaccinated during the national COVID-19 vaccination campaign in China due to concerns about vaccine safety and effectiveness. Here we show that the inactivated COVID-19 vaccine, CoronaVac, is as safe in older people with chronic diseases as it is for healthy people. Also, only slightly differences are seen in the immune response of people with diseases compared to healthy people. Overall, our results highlight that the CoronaVac vaccine is safe and effective in people living with chronic diseases.

引用

共 50 条

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Li, Chunmei
Bi, Hanfang
Fu, Zhenwang
Li, Ao
Wan, Na
Hu, Jun
Yang, Fan
Zhou, Tai-Cheng
Liang, Yupeng
Su, Wei
Shi, Tianpei
Yang, Mei
Wang, Rong
Qin, Wanting
Yu, Xuanjing
Zheng, Hong-Yi
Zhou, Zumi
Zheng, Yong-Tang
Wei, Jia
Zeng, Gang
Zhang, Zijie
Li, Chunmei
Chen, Yanli
Yang, Wei
Ma, Xupu
Bi, Hanfang
Li, Ao
Wan, Na
Wang, Rong
Qin, Wanting
Yu, Xuanjing
Zhou, Zumi
Zhao, Xinshuai
Jiang, Xinyu
Su, Wei
Shi, Tianpei
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Yan, Yating
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[9] Immunogenicity and Safety of an Inactivated SARS-CoV-2 Vaccine: Preclinical Studies
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[10] Immunogenicity, safety and reactogenicity of a heterogeneous booster following the CoronaVac inactivated SARS-CoV-2 vaccine in patients with SLE: a case series
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