Pharmacokinetics and Pharmacodynamics of Cephalosporins in Cerebrospinal Fluid

被引：0
|
作者：
Irja Lutsar
Ian R. Friedland
机构：
[1] Pfizer Global Research & Development Ltd,Sandwich Laboratories
[2] Merck & Co. Inc.,Merck Research Laboratories
来源：
Clinical Pharmacokinetics | 2000年 / 39卷
关键词：
Meningitis; Cephalosporin; Ceftriaxone; Cefotaxime; Bacterial Meningitis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Largely because of their low lipophilicity, cephalosporins poorly penetrate through the blood-brain barrier, achieving relatively low cerebrospinal fluid (CSF) concentrations. However, the minimum bactericidal concentrations (MBCs) of the extended spectrum cephalosporins for common meningeal pathogens are generally low; thus, therapeutic CSF drug concentrations several-fold greater than the MBC can be achieved with currently recommended dosage regimens. However, the effectiveness of cephalosporin therapy is unreliable in patients with meningitis caused by highly penicillin-resistant pneumococci.
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页码：335 / 343
页数：8
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