Induction of photoreceptor-specific phenotypes in adult mammalian iris tissue

被引：0
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作者：
Masatoshi Haruta
Mitsuko Kosaka
Yumi Kanegae
Izumu Saito
Tomoyuki Inoue
Ryoichiro Kageyama
Akihiro Nishida
Yoshihito Honda
Masayo Takahashi
机构：
[1] Kyoto University Graduate School of Medicine,Department of Ophthalmology and Visual Sciences
[2] Japan Science and Technology Corporation/TOREST,undefined
[3] Okayama Technology Center,undefined
[4] 5301 Haga,undefined
[5] Laboratory of Molecular Genetics,undefined
[6] Institute of Medical Science,undefined
[7] University of Tokyo,undefined
[8] Institute for Virus Research,undefined
[9] Kyoto University,undefined
来源：
Nature Neuroscience | 2001年 / 4卷
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摘要：
We show that iris tissue in the adult rat eye, which is embryonically related to the neural retina, can generate cells expressing differentiated neuronal antigens. In addition, the Crx gene transfer induced the specific antigens for rod photoreceptors in the iris-derived cells, which was not seen in the adult hippocampus-derived neural stem cells. Our findings demonstrate a remarkable plasticity of adult iris tissue with potential clinical applications, as autologous iris tissue can be feasibly obtained with peripheral iridectomy.
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页码：1163 / 1164
页数：1
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