Determination of insulin resistance and sensitivity in children and adolescents [Bestimmung von insulinresistenz und insulinsensitivität bei kindern und jugendlichen]

被引：0
|
作者：
Heinze E. [1 ,3 ]
Horn T. [1 ]
Wabitsch M. [1 ]
Wudy S. [2 ]
Sorgo W. [1 ]
Homoki J. [1 ]
机构：
[1] Kinderklinik, Universität Ulm
[2] Kinderklinik, Universität Gießen
[3] Kinderklinik, Universität Ulm, 89075 Ulm
来源：
Monatsschrift Kinderheilkunde | 2002年 / 150卷 / 9期
关键词：
Blood pressure; Body mass index; Insulin resistance; Insulin sensitivity;
D O I：
10.1007/s00112-002-0421-3
中图分类号：
学科分类号：
摘要：
Background. The hyperinsulinimic euglycemic clamp is the gold standard to determine insulin action. In adults simpler methods to define insulin resistance (HOMA) and -sensitivity (ISI) are available. In children/adolescents HOMA and ISI were evaluated and correlated with BMI and blood pressure. Patients. 59 children/adolescents of comparable age were divided into a control group: 23 patients, the Ullrich-Turner group: 14 girls, the obese group: 22 patients. Results. HOMA increased from controls to obesity, while ISI decreased. The association between HOMA and ISI was hyperbolic with R=0.88. The correlation between HOMA and BMI and blood presure was positive and negative for ISI. In one patient the coefficient of variation for HOMA was 30% and 26% for ISI. Conclusion. It appears that in children and adolescents HOMA and ISI may be suitable methods to determine insulin action. © Springer-Verlag 2002.
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页码：1095 / 1100
页数：5
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